Complement and platelet
نویسندگان
چکیده
منابع مشابه
Complement - Dependent Platelet Injury
Blood platelets are involved in a number of immune reactions and, by release of vasoactive amines and thromboplastic factor(s), may contribute to vascular injury and deposition of fibrin (1, 2). Platelet injury can be induced by bacterial endotoxins (3, 4) and immune complexes (5-7), both of which require complement, and by membrane-active bacterial toxins such as streptolysins O and S and stap...
متن کاملPlatelet-bound complement (C3) in immune thrombocytopenia.
The fixation of complement to the circulating platelet in immune thrombocytopenia was detected by measurement of one of the complement components, C3, on the surface of platelets from patients with idiopathic thrombocytopenic purpura (ITP) and systemic lupus erythematosus (SLE) using the anti-C3 consumption assay. The surface IgG was determined simultaneously using the previously described anti...
متن کاملPlatelet‐borne complement proteins and their role in platelet–bacteria interactions
Essentials Platelets play an important role in pathogen recognition. Platelets contain several complement factors and can interact with E. coli. Platelet's complement protein C3 differs from plasmatic C3 in its electrophoretic mobility. Upon contact with bacteria, platelets are activated and can enhance complement activation. SUMMARY Background The role of platelets in immune defense is incre...
متن کاملComplement proteins C5b-9 stimulate procoagulant activity through platelet prothrombinase.
The capacity of platelets treated with nonlytic concentrations of the C5b-9 proteins to catalyze prothrombin activation and thereby trigger clot formation has been investigated. When suspended in the presence of exogenous factors Xa and Va, gel-filtered platelets treated with purified C5b-9 proteins catalyzed prothrombin to thrombin conversion at rates up to tenfold above controls, and exceeded...
متن کاملPlatelet-associated complement C3 in immune thrombocytopenic purpura.
Platelet-associated C3 (PA-C3) was measured with a quantitative immunofluorescence assay. With this assay, PA-C3 levels were determined for 78 normal volunteers, 30 patients with immune thrombocytopenic purpura (ITP), and 20 patients with nonimmune thrombocytopenias. Platelet-associated IgG (PA-IgG) levels were also measured with our standard quantitative immunofluorescence assay. All patients ...
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ژورنال
عنوان ژورنال: Ensho
سال: 1982
ISSN: 0389-4290,1884-4006
DOI: 10.2492/jsir1981.2.4_389